# Chronic Pain Is Brain-Based: 112 Studies, Reviewed

_112 clinical studies from JAMA, Nature, NEJM, and more. The full evidence base showing chronic pain is brain-generated, measurable on fMRI, and reversible._

_Published 2026-04-08 · updated 2026-05-05_

## About the author

**[Tauri Urbanik](https://painapp.health/authors/tauri-urbanik)** — Founder, Painapp · Pain Science Researcher

Founder of Painapp. Writes about neuroplastic pain, Pain Reprocessing Therapy, and nervous system retraining. 3+ years researching chronic pain recovery.

Canonical URL: https://painapp.health/scientific-research

## Medical disclaimer

This page is for educational purposes and is not medical advice. Pain is real. Neuroplastic pain is not imaginary. If you are dealing with chronic pain, please work with a qualified clinician who can evaluate your specific situation.